Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Debate: transfusing to normal haemoglobin levels will not improve outcome.

G Alvarez1, P C Hébert, S Szick

  • 1Department of Medicine, Ottawa Hospital, Ottawa, Ontario, Canada.

Critical Care (London, England)
|April 12, 2001
PubMed
Summary

A restrictive red blood cell transfusion strategy for critically ill patients, targeting a haemoglobin level of 100 g/l, does not worsen mortality or clinical outcomes. This approach also conserves blood resources and reduces costs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ASSeTS: a systematic review and development of the World Health Organization's classification system for social isolation and loneliness interventions.

Population health metrics·2026
Same author

Cross-sectional comparative shotgun metagenomic analysis of the subgingival resistome in healthy subjects and patients with periodontitis from four countries.

Journal of oral microbiology·2026
Same author

Superchilling storage reduces the growth and diversity of bacterial communities associated with Atlantic salmon (Salmo salar) fillets.

Food research international (Ottawa, Ont.)·2025
Same author

Alignment between the research question, design, and terminology is required in manual therapy trials: a methodological study.

Journal of clinical epidemiology·2025
Same author

Magnon damping and mode softening in quantum double-exchange ferromagnets.

Reports on progress in physics. Physical Society (Great Britain)·2025
Same author

Lack of pragmatic attitude of self-labelled pragmatic trials on manual therapy: a methodological review.

BMC medical research methodology·2024

Area of Science:

  • Critical Care Medicine
  • Transfusion Medicine
  • Hematology

Background:

  • Emerging evidence indicates critically ill patients tolerate lower hemoglobin levels.
  • Previous transfusion guidelines were based on assumptions of higher tolerance thresholds.

Purpose of the Study:

  • To evaluate if transfusing red blood cells (RBCs) to a hemoglobin concentration of 100 g/l improves mortality and clinical outcomes in critically ill patients.
  • To support a restrictive transfusion strategy in intensive care settings.

Main Methods:

  • Review of laboratory and clinical studies.
  • Analysis of a recent randomized controlled trial (RCT) in critical care settings.

Main Results:

  • Transfusing to normal hemoglobin concentrations does not improve organ failure or mortality in critically ill patients.

Related Experiment Videos

  • A restrictive transfusion strategy reduces exposure to allogeneic transfusions.

    • Conclusions:

    • A restrictive transfusion strategy, aiming for a hemoglobin level of 100 g/l, is safe and effective for critically ill patients.
    • This strategy leads to more efficient RBC use, overall blood savings, and decreased healthcare costs.