Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alpha-blocker therapy for benign prostatic hyperplasia: a comparative review.

S. Larry Goldenberg1, Ernest Ramsey, John Trachtenberg

  • 1Associate Professor of Surgery (Urology), University of British Columbia, Vancouver, British Columbia.

The Canadian Journal of Urology
|April 12, 2001
PubMed
Summary

Alpha-blockers are now a preferred treatment for benign prostatic hyperplasia (BPH), improving urinary flow and symptoms. While effective, drug selection depends on individual side effect tolerance and administration convenience.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of multiparametric MRI in long-term surveillance following focal laser ablation of prostate cancer.

The British journal of radiology·2021
Same author

Associations between self-reported physical activity, quality of life, and emotional well-being in men with prostate cancer on active surveillance.

Psycho-oncology·2020
Same author

Influence of physical activity on active surveillance discontinuation in men with low-risk prostate cancer.

Cancer causes & control : CCC·2019
Same author

Internet information on focal prostate cancer therapy: help or hindrance?

Nature reviews. Urology·2019
Same author

Pfilates and Hypopressives for the Treatment of Urinary Incontinence After Radical Prostatectomy: Results of a Feasibility Randomized Controlled Trial.

PM & R : the journal of injury, function, and rehabilitation·2019
Same author

Magnetic resonance guided focused high frequency ultrasound ablation for focal therapy in prostate cancer - phase 1 trial.

European radiology·2018

Area of Science:

  • Urology
  • Pharmacology

Background:

  • Pharmacotherapy has replaced surgery as the primary treatment for benign prostatic hyperplasia (BPH).
  • Selective alpha1-adrenoreceptor antagonists are effective and widely used for BPH management.

Purpose of the Study:

  • To review the efficacy and side effect profiles of commonly prescribed alpha-blockers for BPH.
  • To guide clinical decisions in selecting the most appropriate alpha-blocker for individual patients.

Main Methods:

  • Review of randomized controlled trials (RCTs) and non-comparative studies.
  • Analysis of drug efficacy on mean peak urinary flow and BPH symptom severity.
  • Evaluation of reported side effects, including postural hypotension, asthenia, dizziness, and ejaculatory dysfunction.

Related Experiment Videos

Main Results:

  • Terazosin, doxazosin, and tamsulosin significantly improve urinary flow and BPH symptoms.
  • No published trials directly compare the clinical efficacy of these three alpha-blockers.
  • Tamsulosin may have a lower incidence of side effects like postural hypotension, asthenia, and dizziness.
  • Tamsulosin use is associated with ejaculatory dysfunction in 4.5% of men.

Conclusions:

  • The choice between terazosin, doxazosin, and tamsulosin for BPH treatment should be based on patient tolerance for side effects and convenience.
  • Further comparative trials are needed to establish definitive differences in clinical efficacy between these alpha-blockers.