Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence that the renin decrease during hypoxia is adenosine mediated in conscious dogs.

C Höhne1, M O Krebs, W Boemke

  • 1Experimental Anesthesia, Clinics of Anesthesiology and Operative Intensive Care Medicine, Charité, D-13353 Berlin, Germany.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|April 12, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Theory of mind variability in schizophrenia: A neurodevelopmental perspective through neurological soft signs and premorbid adjustment.

Schizophrenia research. Cognition·2025
Same author

Theory of mind in schizophrenia through a clinical liability approach: a sib-pair study.

Frontiers in psychology·2024
Same author

[Postoperative nausea and vomiting-recommendations for its prevention and therapy in paediatric medicine].

Die Anaesthesiologie·2023
Same author

Association and epistatic analysis of white matter related genes across the continuum schizophrenia and autism spectrum disorders: The joint effect of NRG1-ErbB genes.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2021
Same author

Directed, Elliptic, and Higher Order Flow Harmonics of Protons, Deuterons, and Tritons in Au+Au Collisions at sqrt[s_{NN}]=2.4  GeV.

Physical review letters·2021
Same author

[German S1 guideline: obstructive sleep apnea in the context of tonsil surgery with or without adenoidectomy in children-perioperative management].

HNO·2020
Same journal

Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same journal

Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
See all related articles

Adenosine likely reduces plasma renin activity (PRA) during acute hypoxia. Blocking adenosine A(1)-receptors with theophylline prevented this PRA decrease in conscious dogs.

Area of Science:

  • Cardiovascular Physiology
  • Renal Physiology
  • Respiratory Physiology

Background:

  • Acute hypoxia triggers complex physiological responses.
  • The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure regulation.
  • Adenosine's role in mediating hypoxic effects on RAAS is not fully understood.

Purpose of the Study:

  • To investigate if adenosine mediates the decrease in plasma renin activity (PRA) during acute hypoxia.
  • To determine the effect of adenosine receptor antagonism on RAAS suppression under hypoxic conditions.

Main Methods:

  • Conscious beagle dogs with chronic tracheotomies were subjected to normoxia followed by acute hypoxia.
  • Experiments involved intravenous infusion of theophylline, an adenosine A(1)-receptor antagonist.

Related Experiment Videos

  • Plasma renin activity (PRA), angiotensin II (ANG II), and aldosterone concentrations were measured.

    • Main Results:

    • In control experiments, hypoxia significantly decreased PRA, ANG II, and aldosterone.
    • Theophylline administration during hypoxia prevented the decrease in PRA and ANG II.
    • Aldosterone levels decreased during hypoxia independently of theophylline treatment, suggesting a direct hypoxic effect.

    Conclusions:

    • Adenosine likely mediates the suppression of PRA during acute hypoxia in conscious dogs.
    • Theophylline's blockade of adenosine A(1)-receptors inhibits hypoxia-induced RAAS suppression.
    • Hypoxia directly suppresses aldosterone, independent of adenosine-mediated effects on PRA.