Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multiple organ failure in experimental pancreatitis].

B Forgács1, T Foitzik

  • 1Semmelweis Egyetem II. Sz. Sebészeti Klinika, Budapest.

Magyar Sebeszet
|April 13, 2001
PubMed
Summary

Acute necrotizing pancreatitis causes multiple organ failure. Early renal failure is observed, and while fluid resuscitation aids kidney function, it may cause respiratory distress. Endothelin receptor blockade improves both renal and respiratory outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Not Available].

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016
Same author

A prospective cohort study of risk prediction in simultaneous pancreas and kidney transplantation.

Annals of the Royal College of Surgeons of England·2015
Same author

Successful management of a ruptured mycotic pseudoaneurysm following pancreas transplantation using bovine pericardial patch: a case report.

Transplantation proceedings·2014
Same author

[Preparation of ferrum albuminatum saccharatum solubile and a new prescription for liquor ferri albuminati saccharatus].

A Gyogyszeresz·2014
Same author

Outcomes of methicillin-resistant Staphylococcus aureus infection after kidney and/or pancreas transplantation.

Transplantation proceedings·2013
Same author

Third resection of pheochromocytoma aided by preoperative ¹²³I-MIBG scintigraphy and intraoperative gamma probe measurements.

Nuklearmedizin. Nuclear medicine·2011

Area of Science:

  • Gastroenterology
  • Critical Care Medicine
  • Experimental Surgery

Background:

  • Acute necrotizing pancreatitis (ANP) is a severe condition frequently leading to multiple organ failure (MOF).
  • MOF is the primary cause of mortality in patients with ANP.

Purpose of the Study:

  • To investigate the development and progression of MOF in an experimental ANP model.
  • To assess the efficacy of different fluid resuscitation strategies and endothelin receptor blockade in managing MOF complications.

Main Methods:

  • ANP was induced in rats via bile-salt infusion and cerulein hyperstimulation.
  • Animals received varying doses of Ringer's lactate or Ringer's lactate plus an endothelin receptor antagonist.
  • Vital parameters, including hematocrit, urine output, and blood gases, were monitored over 24 hours.

Main Results:

  • Early stages of ANP showed significant hemoconcentration and oliguria.
  • Fluid resuscitation effectively reduced hemoconcentration and compensated blood gas values.
  • High-volume fluid resuscitation led to respiratory compromise (hypoxia, hypercapnia), while endothelin receptor blockade improved renal and respiratory function.

Conclusions:

  • Renal failure is an early complication in this experimental ANP model.
  • Aggressive fluid resuscitation, while improving renal function, can precipitate respiratory distress.
  • Endothelin receptor blockade offers a promising therapeutic strategy by mitigating intravascular fluid loss and improving both renal and respiratory function in ANP.

Related Experiment Videos