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Elevation of serum alkaline phosphatase in clear cell chondrosarcoma of bone
A Ogose1, T Hotta, H Kawashima
1Department of Orthopedic Surgery, Niigata University School of Medicine, Asahimachi 1-751, Niigata 951-8510, Japan.
Background:
Clear cell chondrosarcoma is a rare bone tumor, which is sometimes misdiagnosed as a different bone neoplasm.
Materials And Methods:
The files of 6 patients with clear cell chondrosarcomas were reviewed. Histological slides, radiographic studies, and pre- and post-operative serum alkaline phosphatase (ALP) levels were evaluated. Molecular and histochemical analyses of ALP were documented in one case of clear cell chondrosarcoma.
Results:
Pre-operative serum ALP levels were elevated in 3 patients, and were normal in another 3 patients. After removal of the tumors, the enzyme levels decreased in all patients and returned to normal in 3 patients, who had pre-operative high ALP levels. Enzyme histochemical and molecular analyses demonstrated that the tumor produced ALP.
Conclusion:
Clear cell chondrosarcoma produces ALP, which can be used as a tumor marker in diagnosis and follow-up.