[Hydroxycorticosteroids and the binding capacity of transcrotin in sarcoma 45]

In sarcoma 45 growth the concentration of all fractions of 11-oxycorticosteroids (11--OCS) was found to be increased. Maximum increase in concentration of total and bound 11--OCS was noted on the 7th and 10th day after transplantation. The content of total and bound 11 -- OCS on the 15th and 20th day of tumor growth was close to control values, however, the concentration of free 11 -- OCS exceeded the control level. At the 30th day of the experiment the values of total and bound 11 -- OCS were reliably decreased. While the free hormone content was within control limits. In a progressing malignant growth the binding capacity of transcortin is reduced up to 18.5% (the 30th day of the experiment) that makes 25% of the control value. The content of bound exogenic corticosterone in vitro ranged from 7.7 to 45.2 Mg% in the process of sarcorna 45 growth.