Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intermittent claudication: an objective office-based assessment.

I R McPhail1, P C Spittell, S A Weston

  • 1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.

Journal of the American College of Cardiology
|April 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pregnancy history, coronary artery calcification and bone mineral density in menopausal women.

Climacteric : the journal of the International Menopause Society·2017
Same author

Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders.

Molecular psychiatry·2017
Same author

Endothelial function in women of the Kronos Early Estrogen Prevention Study.

Climacteric : the journal of the International Menopause Society·2014
Same author

Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study.

Journal of internal medicine·2014
Same author

Incidence of venous thromboembolism after elective knee arthroscopic surgery: a historical cohort study.

Journal of thrombosis and haemostasis : JTH·2013
Same author

Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment.

The pharmacogenomics journal·2012
Same journal

Aortic Valve Replacement in Women of Reproductive Age.

Journal of the American College of Cardiology·2026
Same journal

Sudden Death in Cardio-Kidney-Metabolic Patients: Insights From FINE-HEART.

Journal of the American College of Cardiology·2026
Same journal

Ultra-Thin Sirolimus-Eluting Versus Everolimus-Eluting Stents in Diabetic Multivessel Coronary Artery Disease Patients: The TUXEDO-2 Trial.

Journal of the American College of Cardiology·2026
Same journal

Reframing Cardiometabolic Risk and Frailty Through Sarcopenic Obesity.

Journal of the American College of Cardiology·2026
Same journal

Imaging-Derived Sarcopenic Obesity and Cardiovascular Outcomes: Insights Into Heart Failure Risk and Muscle Biology.

Journal of the American College of Cardiology·2026
Same journal

The Measure of a Leader: Lessons in Leadership From Eugene Braunwald.

Journal of the American College of Cardiology·2026
See all related articles

Active pedal plantarflexion offers a safe and economical alternative to treadmill exercise for assessing lower extremity arterial occlusive disease. This noninvasive office-based test shows excellent correlation with traditional methods, reducing patient symptoms.

Area of Science:

  • Vascular Medicine
  • Noninvasive Diagnostic Techniques
  • Cardiovascular Health

Background:

  • Intermittent claudication is prevalent in elderly individuals, signaling increased cardiovascular risk.
  • Diagnosis and severity assessment of lower extremity arterial occlusive disease often require noninvasive vascular laboratory testing.
  • Traditional testing involves treadmill exercise and ankle-brachial systolic blood pressure indices in a formal setting.

Purpose of the Study:

  • To compare the efficacy of standard lower extremity vascular laboratory treadmill exercise with an office-based active pedal plantarflexion technique.
  • To evaluate the correlation and safety of active pedal plantarflexion versus treadmill exercise for assessing arterial occlusive disease.

Main Methods:

  • A prospective, randomized crossover study involving 50 patients with suspected intermittent claudication.

Related Experiment Videos

  • Patients underwent both lower extremity treadmill exercise testing and active pedal plantarflexion testing.
  • Supine ankle-brachial systolic blood pressure indices were measured pre- and post-exercise for both methods.
  • Main Results:

    • Excellent correlation (r = 0.95) was observed between postexercise ankle-brachial systolic blood pressure indices from both testing methods.
    • No significant differences in outcomes were found based on testing order or disease severity.
    • Active pedal plantarflexion resulted in zero instances of angina or dyspnea, compared to 22% with treadmill exercise.

    Conclusions:

    • Active pedal plantarflexion is a noninvasive, safe, objective, and economical method for assessing lower extremity arterial occlusive disease.
    • This office-based technique favorably compares with traditional treadmill exercise testing.
    • The active pedal plantarflexion test offers a more comfortable and symptom-free alternative for patients.