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Stereoselective reduction with NADH model BNAH through chiral induction in cyclodextrins
1Department of Chemistry, University of Science and Technology of China, Hefei, 230026, People's Republic of China. ycliu@ustc.edu.cn
Bioorganic Chemistry
|April 13, 2001
Abstract:
Stereoselective reductive debromination-cyclopropanation of 2-bromo-1-phenylethylidene-malononitrile and 2-bromo-1-beta-naphthylethylidenemalononitrile by coenzyme NADH model BNAH through chiral induction in cyclodextrins is reported. The matching between substrates and cyclodextrins, the substituent effect, and the effect of cyclodextrin concentration on the optical yields have been investigated.