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A combinatorial approach to [1,5]benzothiazepine derivates as potential antibacterial agents
F Micheli1, F Degiorgis, A Feriani
1GlaxoWellcome Medicine Research Centre, V. Fleming, 4-37135 Verona, Italy, Nucleotide Analog Pharma AG, Landsberger Strasse, 50 - 80339 Munchen, Germany.
Journal of Combinatorial Chemistry
|April 13, 2001
Abstract:
[1,5]Benzothiazepines are widely used in a number of different therapeutic areas and therefore represent an interesting scaffold for de novo exploration. Recent literature reports suggest their value as antibacterial agents. The present paper reports the exploration of this scaffold for the generation of combinatorial libraries both in solution and on solid phase.