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Blastomyces dermatitidis with large yeast forms.

Z Hussain1, A Martin, G A Youngberg

  • 1Department of Pathology, PO Box 70568, East Tennessee State University, Johnson City, TN 37614, USA. hzakir@hotmail.com

Archives of Pathology & Laboratory Medicine
|April 13, 2001
PubMed
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Giant yeast forms of Blastomyces dermatitidis, measuring 30-35 microm, were observed in a rare case of pulmonary blastomycosis. This unusual morphology may be linked to immunosuppression, particularly glucocorticoid use.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pathology

Background:

  • Blastomyces dermatitidis is a fungus causing blastomycosis, a potentially severe infection.
  • Typical yeast forms of B. dermatitidis measure 8–20 microm in diameter.
  • Primary pulmonary blastomycosis presents with diverse clinical and morphological manifestations.

Observation:

  • A rare case of primary pulmonary blastomycosis exhibited unusual fungal morphology.
  • Significantly enlarged yeast forms of B. dermatitidis, measuring 30–35 microm, were identified.
  • This represents the second reported instance of giant yeast forms of B. dermatitidis.

Findings:

  • The study identified unusually large yeast forms of Blastomyces dermatitidis.
  • These giant forms (30–35 microm) are rare, with only one prior report.

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  • A potential association between giant yeast morphology and immunosuppression was noted.
  • Implications:

    • This finding expands the known morphological spectrum of Blastomyces dermatitidis.
    • Further research is warranted to understand the pathobiology of giant yeast forms.
    • The association with immunosuppression, especially glucocorticoid use, requires further investigation for clinical relevance.