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Updated: Aug 9, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

Modulation of ligand responses by coupling of alpha(2A)-adrenoceptors to diverse G(alpha)-proteins

P J Pauwels1, S Tardif, F C Colpaert

  • 1Department of Cellular and Molecular Biology, Centre de Recherche Pierre Fabre, 17 Avenue Jean Moulin, F-81106, Castres Cédex, France. peter.pauwels@pierre-fabre.com

Biochemical Pharmacology
|April 13, 2001
PubMed

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G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Activation and Inactivation of G Proteins

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GPCRs Regulate Adenylyl Cylase Activity

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G Protein-coupled Receptors

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Adrenergic Receptors: ɑ Subtype

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