Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary hypomagnesemia. I. Absorption Studies.

I Lombeck, F Ritzl, H G Schnippering

    Zeitschrift Fur Kinderheilkunde
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chemoproteomic Profiling of PKA Substrates with Kinase-catalyzed Crosslinking and Immunoprecipitation (K-CLIP).

    bioRxiv : the preprint server for biology·2025
    Same author

    Instrumental variable estimation of the marginal structural Cox model for time-varying treatments.

    Biometrika·2023
    Same author

    A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity.

    American journal of physiology. Lung cellular and molecular physiology·2018
    Same author

    Discussion of "A risk-based measure of time-varying prognostic discrimination for survival models," by C. Jason Liang and Patrick J. Heagerty.

    Biometrics·2016
    Same author

    TGF-β-mediated airway tolerance to allergens induced by peptide-based immunomodulatory mucosal vaccination.

    Mucosal immunology·2015
    Same author

    Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects.

    The pharmacogenomics journal·2014

    Primary hypomagnesemia in an infant was successfully treated with trimagnesium dicitrate. This condition significantly reduced magnesium absorption and retention, indicating a genetic basis distinct from parental levels.

    Area of Science:

    • Biochemistry
    • Pediatrics
    • Genetics

    Background:

    • Primary hypomagnesemia is a rare disorder affecting magnesium balance.
    • Understanding its clinical course and genetic basis is crucial for effective management.

    Purpose of the Study:

    • To report the clinical course of two patients with primary hypomagnesemia.
    • To investigate magnesium metabolism in a pediatric patient.
    • To evaluate treatment efficacy.

    Main Methods:

    • Case study of two patients with primary hypomagnesemia.
    • Detailed measurements of magnesium retention, intestinal absorption, fecal excretion, and renal clearance using 28-Mg.
    • Genetic analysis of familial magnesium retention values.
    • Clinical observation during treatment with trimagnesium dicitrate.

    Related Experiment Videos

    Main Results:

    • One male infant showed markedly reduced magnesium retention (2.8%) and absorption (7.8%) compared to controls (25% and 28%, respectively).
    • Parental and relative magnesium retention values were within the normal range for healthy adults.
    • The infant patient was successfully treated with trimagnesium dicitrate, receiving 1.75 g of magnesium daily.

    Conclusions:

    • Primary hypomagnesemia can present with severe defects in intestinal magnesium absorption and retention in infants.
    • The condition appears to have a genetic component, as evidenced by normal parental values.
    • Trimagnesium dicitrate is an effective treatment for primary hypomagnesemia in pediatric patients.