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Updated: Aug 2, 2026
06:03
Electrolytic Inferior Vena Cava Model (EIM) of Venous Thrombosis
Published on: July 12, 2011
[Olav Egeberg--hereditary antithrombin deficiency and thrombophilia]
1Medisinsk klinikk, Aker sykehus, 0514 Oslo. ulrich.abildgaard@ioks.uio.no
Summary
Olav Egeberg
Area of Science:
- Hematology
- Genetics
- Clinical Medicine
Background:
- The 1965 study by Olav Egeberg identified a hereditary defect in blood coagulation control linked to thrombotic disease.
- Egeberg's research focused on a family with a history of venous thrombosis.
Discussion:
- The study demonstrated subnormal antithrombin and heparin cofactor activity in affected family members.
- This finding supported the hypothesis of a single protein responsible for both activities.
- The condition was inherited in an autosomal dominant pattern.
Key Insights:
- First report linking a hereditary defect in blood coagulation to thrombotic disease.
- Identification of antithrombin deficiency as a cause of inherited thrombophilia.
- Established the autosomal dominant inheritance pattern of this coagulation disorder.
Outlook:
- Egeberg's publication pioneered the field of thrombophilia research.
- Established thrombophilia as a significant clinical discipline.
- Laid the groundwork for understanding inherited thrombotic risk factors.
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