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Apolipoprotein H is increased in type 2 diabetic patients with microalbuminuria
P Cavallo Perin1, G Gruden, S Giunti
1Department of Internal Medicine, University of Turin, Turin, Italy.
Background And Aim:
Serum apolipoprotein H (Apo H) levels are increased in hyperlipidemic subjects and type 2 diabetics, but unknown in microalbuminuria, another disorder with an increased cardiovascular risk. We looked to see whether increased Apo H levels are associated with microalbuminuria in type 2 diabetes.
Methods And Results:
Serum Apo H was calculated in 20 normoalbuminuric and 17 microalbuminuric type 2 diabetics matched for age, sex, body mass index (BMI), glycosylated haemoglobin, plasma lipids and duration of diabetes, and also compared with 20 non-diabetic controls matched for age, sex, BMI and plasma lipids. Mean serum Apo H was significantly higher in the microalbuminuric patients (31.12 +/- 1.58 SEM vs 25.25 +/- 1.52 and 24.72 +/- 0.99 mg/dL, p = 0.003).
Conclusion:
Serum apo H levels are increased in type 2 diabetics with microalbuminuria.