Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Expression of basic fibroblast growth factor during distraction osteogenesis.

H Y Yeung1, S K Lee, K P Fung

  • 1Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT.

Clinical Orthopaedics and Related Research
|April 17, 2001
PubMed
Summary

Basic fibroblast growth factor (bFGF) expression is elevated during distraction osteogenesis in goats, particularly in osteoblasts and mesenchymal cells. This suggests bFGF plays a key role in bone regeneration under mechanical stress.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Compositional data modeling of high-dimensional single cell RNA-seq (CoDA-hd): its advantages over commonly used normalization approaches.

Journal of translational medicine·2025
Same author

Chinese university students' help-seeking behaviors when faced with mental health challenges.

Journal of mental health (Abingdon, England)·2024
Same author

Danshen Gegen capsule for intermittent claudication in patients with peripheral arterial disease: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2021
Same author

Combination of atorvastatin or hydrochlorothiazide/amlodipine with <i>Salvia miltiorrhiza</i> (Danshen) and <i>Pueraria lobata</i> (Gegen) for atherosclerosis, hyperlipidaemia, and hypertension: a preclinical in vivo study (abridged secondary publication).

Hong Kong medical journal = Xianggang yi xue za zhi·2021
Same author

The impact of particulate matter air pollution (PM2.5) on atherosclerosis in modernizing China: a report from the CATHAY study.

International journal of epidemiology·2020
Same author

Combined use of <i>Andrographis paniculata</i> and chemotherapeutics for metastatic oesophageal cancer: a pre-clinical study.

Hong Kong medical journal = Xianggang yi xue za zhi·2020

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biochemistry

Background:

  • Distraction osteogenesis is a critical surgical technique for bone reconstruction.
  • Understanding the molecular mechanisms driving bone regeneration is essential for improving outcomes.
  • Basic fibroblast growth factor (bFGF) is a key signaling molecule implicated in tissue repair.

Purpose of the Study:

  • To investigate the spatial and temporal expression of basic fibroblast growth factor (bFGF) during distraction osteogenesis in a goat model.
  • To determine the cellular localization of bFGF within the regenerating bone tissue.
  • To elucidate the potential role of bFGF in the mechanical stimulation-induced bone regeneration process.

Main Methods:

  • Immunohistochemistry was employed to detect bFGF expression.

Related Experiment Videos

  • The study utilized a goat model undergoing distraction osteogenesis.
  • Expression patterns were analyzed during distraction, latency, and consolidation phases.

    • Main Results:

    • Basic fibroblast growth factor (bFGF) was expressed in osteoblasts and mesenchymal cells within the distraction callus.
    • Higher bFGF expression was observed during the distraction phase compared to latency and consolidation phases.
    • Sustained bFGF expression was noted in some osteoblasts even during consolidation.

    Conclusions:

    • Basic fibroblast growth factor (bFGF) likely plays a localized regulatory role in distraction osteogenesis.
    • Tensile forces during distraction may stimulate bFGF expression in osteoblasts and other relevant cell types.
    • These findings highlight bFGF as a potential therapeutic target for enhancing bone regeneration.