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Updated: Aug 17, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
Use of hydrophobic moment plot methodology to aid the identification of oblique orientated alpha-helices
F Harris1, J Wallace, D A Phoenix
1Centre for Forensic Science, University of Central Lancashire, Preston, UK.
Abstract:
A number of alpha-helix forming peptides have been reported which appear to promote membrane fusion and other biological events related to the disruption of a hydrophobic/hydrophilic interface, due to the presence of a hydrophobicity gradient along the helical long axis. When alpha-helices from this class were analysed according to hydrophobic moment plot methodology a linear association was found to exist between the mean hydrophobic moment,
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