Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pneumococcal resistance: the treatment challenge.

G W Amsden1, K Amankwa

  • 1Department of Pharmacy, Clinical Pharmacology Research Center, Bassett Healthcare, Cooperstown, NY 13326-1394, USA. guy.amsden@bassett.org

The Annals of Pharmacotherapy
|April 17, 2001
PubMed
Summary

Pneumococcal antibiotic resistance is increasing, but appropriate antimicrobial dosing and pneumococcal vaccines can help manage this challenge. Correctly used older antibiotics may still be effective against resistant strains.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma Pharmacokinetics and Tissue Penetration of Alatrofloxacin in Morbidly Obese Individuals.

Clinical drug investigation·2016
Same author

Pharmacokinetic study of azithromycin with fluconazole and cotrimoxazole (trimethoprim-sulfamethoxazole) in healthy volunteers.

Clinical drug investigation·2013
Same author

Pharmacokinetics of Oral Azithromycin in Serum, Urine, Polymorphonuclear Leucocytes and Inflammatory vs Non-Inflammatory Skin Blisters in Healthy Volunteers.

Clinical drug investigation·2008
Same author

Anti-inflammatory effects of macrolides--an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?

The Journal of antimicrobial chemotherapy·2004
Same author

Pharmacokinetics of intravenous azithromycin and ceftriaxone when administered alone and concurrently to healthy volunteers.

The Journal of antimicrobial chemotherapy·2002
Same author

A case of pneumocephalus secondary to blunt head trauma.

The Journal of emergency medicine·2001

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Increasing incidence of pneumococcal antibiotic resistance poses a significant clinical challenge.
  • Resistance trends have led to shifts in treatment strategies, often involving newer antibiotics.
  • Controversies exist regarding the necessity of switching to newer antibiotic classes.

Purpose of the Study:

  • To review in vitro and in vivo data on pneumococcal antibiotic resistance.
  • To analyze the incidence, mechanisms, and controversies of this growing problem.
  • To provide clinicians with recommendations for treatment and prevention.

Main Methods:

  • Comprehensive literature search of MEDLINE (1966-August 2000) and secondary resources.
  • Inclusion of primary and review articles.

Related Experiment Videos

  • Evaluation of all identified relevant information for synthesis.

    • Main Results:

    • Growing incidence of multi-drug resistant pneumococcal isolates is a troubling trend.
    • Shifting to newer antibiotics may not always be necessary for resistant pneumococci.
    • Pharmacokinetic and pharmacodynamic data suggest some older antibiotics may remain effective with correct usage.

    Conclusions:

    • Appropriate antimicrobial dosing is crucial for managing pneumococcal resistance.
    • Optimal use of pneumococcal vaccines can help slow resistance development.
    • Judicious use of antimicrobials can prolong the efficacy of existing agents.