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Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase
K Gerth1, H Steinmetz, G Höfle
1GBF, Gesellschaft für Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie, Braunschweig, Germany. kge@gbf.de
The Journal of Antibiotics
|April 17, 2001
Abstract:
Nonproducer mutants support the assumption that epothilones A and B are synthesized by the same polyketide synthase (PKS). The endproducts of the PKS, epothilones C and D, compete for the active site of a constitutively synthesized monooxygenase which is regulated by product inhibition. The postulated C-13 hydroxy-epothilones as direct precursors of epothilones C and D were not detected.