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Tolerance and pharmacokinetic interactions of rifabutin and azithromycin
R Hafner1, J Bethel, H C Standiford
1Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. RHafner@niaid.nih.gov
Antimicrobial Agents and Chemotherapy
|April 17, 2001
Abstract:
This multicenter study evaluated the tolerance and potential pharmacokinetic interactions between azithromycin and rifabutin in volunteers with or without human immunodeficiency virus infection. Daily dosing with the combination of azithromycin and rifabutin was poorly tolerated, primarily because of gastrointestinal symptoms and neutropenia. No significant pharmacokinetic interactions were found between these drugs.