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Related Experiment Videos

Ischemia in aortic stenosis: hemodynamic prediction.

G Buckberg, L Eber, M Herman

    The American Journal of Cardiology
    |June 1, 1975
    PubMed
    Summary

    Hemodynamic indexes, specifically the diastolic pressure-time index/tension-time index ratio, can predict myocardial ischemia in aortic stenosis patients. This helps differentiate ischemia causes and aids in clinical assessment.

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    Area of Science:

    • Cardiology
    • Cardiovascular Physiology

    Background:

    • Aortic stenosis can lead to myocardial ischemia.
    • Predicting ischemia in these patients is clinically important.

    Purpose of the Study:

    • To evaluate hemodynamic indexes for predicting myocardial ischemia in aortic stenosis patients.
    • To assess the role of coronary artery disease in ischemia development.

    Main Methods:

    • Review of 12 patients with aortic stenosis studied before and after isoproterenol infusion.
    • Calculation of diastolic pressure-time index (DPTI) and tension-time index (TTI).
    • Assessment of myocardial lactate metabolism and calculation of the DPTI/TTI supply/demand ratio.

    Main Results:

    • Patients with aortic stenosis alone showed ischemia when DPTI/TTI < 0.30.
    • Patients with aortic stenosis and coronary artery disease exhibited abnormal lactate metabolism with varying DPTI/TTI ratios.
    • Aortic valve areas were comparable across groups.

    Conclusions:

    • The DPTI/TTI ratio is a useful index for predicting ischemia in aortic stenosis.
    • This ratio can help distinguish the contribution of coronary artery disease.
    • It serves as an adjunct to valve area calculation, without needing regurgitation quantitation.

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