Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exercise and interleukin-6.

B K Pedersen1, A Steensberg, P Schjerling

  • 1The Copenhagen Muscle Research Center, Rigshospitalet, Denmark. bkp@rh.dk

Current Opinion in Hematology
|April 17, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepcidin-The Culprit Explaining Disturbed Iron Homeostasis in Chronic Renal Disease?: IL-6 Mediates Hypoferremia of Inflammation by Inducing the Synthesis of the Iron Regulatory Hormone Hepcidin. J Clin Invest 113:1271-1276, 2004.

Journal of the American Society of Nephrology : JASN·2023
Same author

Acute loading has minor influence on human articular cartilage gene expression and glycosaminoglycan composition in late-stage knee osteoarthritis: a randomised controlled trial.

Osteoarthritis and cartilage·2023
Same author

The regional turnover of cartilage collagen matrix in late-stage human knee osteoarthritis.

Osteoarthritis and cartilage·2022
Same author

Effects of high-intensity exercise training on physical fitness, quality of life and treatment outcomes after oesophagectomy for cancer of the gastro-oesophageal junction: PRESET pilot study.

BJS open·2020
Same author

An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise.

Scientific reports·2019
Same author

Dysregulated autophagy in muscle precursor cells from humans with type 2 diabetes.

Scientific reports·2019
Same journal

Dynamic myeloid suppressor states in cancer and inflammation and their therapeutic potential.

Current opinion in hematology·2026
Same journal

Factor XIa inhibition for the prevention of thrombosis: mechanism, clinical trial signals, and indication-specific positioning.

Current opinion in hematology·2026
Same journal

Nutrition as a regulator of hematopoietic stem cell biology and transplantation.

Current opinion in hematology·2026
Same journal

From biomimicry to clinical actionability: rethinking high-shear thrombosis as a mechanobiological system.

Current opinion in hematology·2026
Same journal

Bidirectional relationship between metabolic and thrombotic disease mechanisms.

Current opinion in hematology·2026
Same journal

The dual role of the brain-derived neurotrophic factor as a regulator of hemostasis and thrombotic risk.

Current opinion in hematology·2026
See all related articles

Strenuous exercise significantly increases cytokines like interleukin-6 (IL-6) in the blood. Produced in muscles, IL-6 links exercise to metabolic changes such as glucose production and fat breakdown.

Area of Science:

  • Exercise physiology
  • Immunology
  • Metabolic research

Background:

  • Strenuous exercise triggers the release of various pro-inflammatory and anti-inflammatory cytokines, inhibitors, and chemokines.
  • Elevated plasma levels of tumor necrosis factor-alpha, interleukins (IL-1 beta, IL-10, IL-6, IL-8), IL-1 receptor antagonist, TNF-receptors, and macrophage inflammatory protein-1 are observed post-exercise.

Purpose of the Study:

  • To investigate the role of interleukin-6 (IL-6) in exercise-induced metabolic alterations.
  • To determine the source and significance of exercise-induced IL-6 production.

Main Methods:

  • Analysis of plasma cytokine levels following strenuous exercise.
  • Investigation of IL-6 production site in skeletal muscle.
  • Assessment of IL-6's metabolic effects, including hepatic glucose output and lipolysis.

Related Experiment Videos

Main Results:

  • Interleukin-6 (IL-6) concentration can increase up to 100-fold after marathon running.
  • IL-6 is produced locally within contracting skeletal muscles, accounting for increased arterial concentrations.
  • IL-6 production surpasses other cytokines in response to exercise.

Conclusions:

  • Interleukin-6 (IL-6) is a key mediator linking skeletal muscle activity during exercise to metabolic adjustments.
  • IL-6's ability to stimulate hepatic glucose output and lipolysis highlights its central role in exercise metabolism.