Titrating dietary linoleate to in vivo platelet function in man

Platelet aggregation time significantly increased within 48 hours in response to an increase in dietary linoleate of 4% of calories while disaggregation time decreased significantly in 96 hours. A change as small as 0.5% of calories was associated with significant alterations within 4 days. In this group, dietary linoleate appears to be related to platelet function by the equations Aggregation time equals 41.14 plus 2.79 linoleate Disaggregation time equals 11.04 minus 25.52 linoleate.