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Related Experiment Videos

Ampicillin-associated diarrhea--A prospective study.

F J Tedesco

    The American Journal of Digestive Diseases
    |April 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Ampicillin use in 200 patients altered bowel habits in 16% and caused diarrhea in 4.5%. Higher ampicillin doses increased these effects, with no pseudomembranous colitis observed.

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    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Antibiotic-associated diarrhea is a common clinical concern.
    • Pseudomembranous colitis is a severe complication linked to certain antibiotics.
    • Ampicillin is a widely used antibiotic with potential gastrointestinal side effects.

    Purpose of the Study:

    • To investigate the incidence of altered bowel habits and diarrhea associated with ampicillin use.
    • To determine the relationship between ampicillin dosage and route of administration on gastrointestinal side effects.
    • To provide a comparative perspective for antibiotic-associated colitis.

    Main Methods:

    • Prospective study design.
    • Inclusion of 200 consecutive patients receiving ampicillin.

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  • Monitoring and recording of changes in bowel habits and occurrence of diarrhea.

    • Main Results:

    • 16% of patients experienced altered bowel habits.
    • 4.5% of patients developed diarrhea.
    • Increased total ampicillin dosage correlated with a higher incidence of altered bowel habits.
    • Both oral and intravenous routes of ampicillin administration showed similar incidences of altered bowel habits.
    • No cases of pseudomembranous colitis were identified.

    Conclusions:

    • Ampicillin is associated with a notable incidence of altered bowel habits and diarrhea.
    • Dosage is a significant factor influencing ampicillin-induced gastrointestinal disturbances.
    • The findings offer a baseline for understanding the risks of other antibiotics, such as clindamycin, in causing colitis.