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Persistent subclinical inflammation among A-bomb survivors
K Neriishi1, E Nakashima, R R Delongchamp
1Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan. neriishi@rerf.or.jp
International Journal of Radiation Biology
|April 17, 2001
Summary
Radiation exposure in atomic bomb survivors is linked to increased inflammation markers. This association, observed between 1988-1992, may contribute to radiation-induced disorders through epigenetic or bystander effects.
Area of Science:
- Radiation effects research
- Biomarkers of inflammation
- Atomic bomb survivor studies
Background:
- Atomic bomb survivors are a unique cohort for studying long-term health effects of radiation.
- Inflammation is implicated in various chronic diseases and may be a mechanism through which radiation exerts its effects.
Purpose of the Study:
- To investigate the relationship between radiation dose and specific inflammation markers in atomic bomb survivors.
- To explore potential heterogeneity in these associations based on pre-existing conditions.
Main Methods:
- Analysis of inflammation tests (leukocyte counts, erythrocyte sedimentation rate, globulin levels, sialic acid) from atomic bomb survivors between 1988-1992.
- Regression analysis to assess associations with radiation dose (DS86).
- Testing for heterogeneity related to inflammatory diseases, anemia, or cancer history.
Main Results:
- Statistically significant associations were found between radiation dose and leukocyte counts, erythrocyte sedimentation rate, corrected erythrocyte sedimentation rate, alpha-1 globulin, alpha-2 globulin, and sialic acid.
- No significant association was observed for neutrophil counts.
- Associations were strongest for chronic thyroiditis and chronic liver diseases among inflammatory conditions.
Conclusions:
- A statistically significant association exists between inflammation markers and radiation dose in atomic bomb survivors.
- This association may play a role in the development of radiation-induced disorders via epigenetic or bystander effects.