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Related Experiment Videos

Acute ketamine intoxication treated by haloperidol: a preliminary study.

A J Giannini1, N A Underwood, M Condon

  • 1Chemical Abuse Centers, Inc., Austintown, OH, USA.

American Journal of Therapeutics
|April 17, 2001
PubMed
Summary

Haloperidol effectively treated symptoms in individuals who mistakenly ingested ketamine, believing it was phencyclidine. This study highlights haloperidol

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Toxicology

Background:

  • Phencyclidine (PCP) intoxication is a significant clinical concern.
  • Ketamine is sometimes mistaken for PCP due to similar psychoactive effects.
  • Effective management of dissociative anesthetic intoxication is crucial.

Purpose of the Study:

  • To evaluate the efficacy of haloperidol in managing ketamine intoxication.
  • To compare haloperidol treatment against an active placebo in this specific patient group.

Main Methods:

  • An open, double-blind study design was employed.
  • Twenty-one male subjects mistakenly ingesting ketamine were enrolled.
  • Subjects received either intramuscular haloperidol (5 mg) or an active placebo.

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Main Results:

  • Haloperidol administration led to a significant reduction in psychiatric symptoms.
  • The Brief Psychiatric Rating Scale (BPRS) was used for symptom assessment.
  • No significant difference was noted in the placebo group.

Conclusions:

  • Intramuscular haloperidol is an effective treatment for ketamine intoxication.
  • This finding is relevant for emergency medicine and psychiatric settings.
  • Accurate diagnosis is critical, as treatment may differ based on the specific substance ingested.