Related Experiment Video
Updated: Aug 10, 2026
Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System
Published on: September 20, 2018
Hormone replacement therapy plus pelvic floor muscle exercise for postmenopausal stress incontinence. A randomized,
1Department of Obstetrics and Gynecology, Osaka City University Medical School, and Hanwa Sumiyoshi General Hospital, Osaka, Japan. ishikoo@msic.med.osaka-cu.ac.jp
Objective:
To investigate the effects of the combination of pelvic floor muscle exercise (PFME) and estriol on postmenopausal stress incontinence (SI).
Study Design:
Sixty-six patients with postmenopausal SI were randomized to a group treated with a combination of estriol (1 mg/d) and PFME (group A, n = 32) and a group treated with PFME alone (group B, n = 34). Efficacy was evaluated every three months based on stress scores obtained from a urinary incontinence (UI) questionnaire.
Results:
A significant decrease in stress score was observed in mild and moderate UI patients in both groups three months after the commencement of therapy (A and B, P < .0001). The therapeutic effect in group A was more prominent for up to 18 months in mild UI and for up to 12 months in moderate UI (A vs. B, P < .05). Kaplan-Meier analysis showed that the cumulative morbidity rate in mild SI patients was significantly lower in group A (0%) than in group B (12%, P < .005).
Conclusion:
Combination therapy with estriol plus PFME was effective and is capable of serving as first-line treatment for mild SI.
