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[Extended-spectrum beta-lactamases (ESBLs) producing bacteria].

Y Hirakata1

  • 1Department of Laboratory Medicine, Nagasaki University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|April 18, 2001
PubMed
Summary

Extended-spectrum beta-lactamases (ESBLs) like TEM and SHV are emerging in Japan. A new detection system is needed due to the prevalence of Toho-1 and other ESBL types.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Clinical Science

Context:

  • Extended-spectrum beta-lactamases (ESBLs) of the TEM and SHV types, prevalent in Europe and the US, were historically absent in Japan.
  • Toho-1, a unique class A ESBL, emerged in Japan in 1995 and is now the predominant ESBL type.
  • Recent years have seen the emergence of various SHV-derived ESBLs (e.g., SHV-24) and TEM-26 in Japan.

Purpose:

  • To highlight the changing landscape of ESBL prevalence in Japan.
  • To underscore the need for a specialized detection system for ESBLs in Japan, considering the diverse enzyme types.
  • To address the clinical concern posed by the increasing number of ESBL-producing bacterial strains in Japan.

Summary:

  • While TEM- and SHV-type ESBLs were initially rare in Japan, the emergence of Toho-1 in 1995 marked a significant shift.
  • Japan now faces a complex ESBL profile, including Toho-1, various SHV derivatives (SHV-2, SHV-5α, SHV-12, SHV-24), and TEM-26.
  • The widespread presence of Toho-1-type ESBLs, AmpC-type beta-lactamases, and class B metallo-beta-lactamases necessitates the development of a novel, Japan-specific ESBL detection system.

Impact:

  • The findings necessitate the development of advanced diagnostic tools for accurate and timely identification of ESBLs in Japanese clinical settings.
  • Understanding the evolving epidemiology of ESBLs in Japan is crucial for effective antimicrobial stewardship and infection control.
  • This research informs the development of targeted strategies to combat antimicrobial resistance driven by diverse ESBLs in Japan.

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