Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Suggestions from a centenarian study--aging and inflammation].

N Hirose1, Y Arai, K Yamamura

  • 1Department of Geriatric Medicine, Keio University School of Medicine.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|April 18, 2001
PubMed
Summary

Successful aging in centenarians is linked to low nutritional markers and high inflammation. Interventions targeting inflammation and homocysteine may improve quality of life for the oldest old.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consistent disruption of the AML1 gene occurs within a single intron in the t(8;21) chromosomal translocation.

Cancer research·1992
Same author

Retrovirus-mediated gene transfer targeted to malignant glioma cells in murine brain.

Japanese journal of cancer research : Gann·1992
Same author

Intrathecal chemotherapy with ACNU for meningeal gliomatosis.

British journal of cancer·1992
Same author

Kyphoscoliosis in polyostotic fibrous dysplasia. A case report.

Spine·1992
Same author

[Surgical treatment of infected left atrial myxoma--a case report].

[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai·1992
Same author

Posterior decompression and stabilization for multiple metastatic tumors of the spine.

Spine·1992

Area of Science:

  • Gerontology and Longevity Research
  • Biomarkers of Aging
  • Nutritional Science

Context:

  • The global population of the oldest old is rapidly increasing, highlighting the need to understand factors contributing to successful aging and autonomy.
  • Centenarians represent a unique cohort for studying extreme longevity and the biological characteristics associated with aging.
  • Investigating the health status of centenarians provides insights into maintaining function and independence in advanced age.

Purpose:

  • To investigate the specific health characteristics of centenarians in Tokyo.
  • To examine the relationship between nutritional status, inflammation, homocysteine levels, and the observed characteristics of centenarians.
  • To propose a hypothesis explaining the biological underpinnings of successful aging in extreme longevity.

Related Experiment Videos

Summary:

  • Centenarians in Tokyo exhibit low levels of nutritional parameters, cholesterol, HDL-cholesterol, red blood cells, and hemoglobin.
  • Elevated levels of C-reactive protein (CRP) and homocysteine, along with high von Willebrand factor, are characteristic of this cohort.
  • Albumin levels correlate with lipid profiles, red blood cells, activities of daily living (ADL), and cognitive function, indicating a link between nutrition and function.
  • CRP levels are associated with albumin, suggesting inflammation is intertwined with nutritional status.
  • Homocysteine levels correlate with von Willebrand factor, pointing to a role in endothelial injury.
  • A high incidence of dementia (59.3%) was observed among the centenarians.

Impact:

  • The findings suggest that a proinflammatory state is associated with aging and contributes to the characteristics observed in centenarians.
  • Homocysteine appears to play a role in endothelial injury, a common issue in aging.
  • Interventions aimed at suppressing inflammation and reducing homocysteine levels hold potential for improving the quality of life (QOL) for the oldest old.
  • This research provides a basis for developing targeted strategies to promote healthy aging and maintain autonomy in advanced years.