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Updated: Aug 17, 2026

Imaging of Biological Tissues by Desorption Electrospray Ionization Mass Spectrometry
Published on: July 12, 2013
Desorption-ionization mass spectrometry using deposited nanostructured silicon films
J D Cuiffi1, D J Hayes, S J Fonash
1Nanofabrication Facility, The Pennsylvania State University, University Park 16802, USA. jdc167@psu.edu
Abstract:
We present a method for desorption ionization on silicon based on novel column/void-network-deposited silicon thin films. A number of different peptides and proteins in the < or = 6000 Daltons range are analyzed by time-of-flight mass spectrometry in this demonstration of our approach. A variety of sample preparation conditions, including the use of chemical additives, surface treatments, and sample purification are used to show the potential of mass analysis using deposited column/void-network silicon films for high throughput proteomic screening.
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