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Updated: Jul 25, 2026

Caspase-3 Activity in the Rat Amygdala Measured by Spectrofluorometry After Myocardial Infarction
Published on: January 12, 2016
Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology
1Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697-4540, USA. josephsu@uci.edu
Abstract:
Several studies have suggested that activated caspase-3 has properties of a cell death executioner protease. In this study, we examined the expression of activated caspase-3 in AD and aged control brains. Activated caspase-3 immunoreactivity was seen in neurons, astrocytes, and blood vessels, was elevated in AD, and exhibited a high degree of colocalization with neurofibrillary tangles and senile plaques. These data suggest that activated caspase-3 may be a factor in functional decline and may have an important role in neuronal cell death and plaque formation in AD brain.
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