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Variation in mammographic breast density by race
A Y El-Bastawissi1, E White, M T Mandelson
1Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
Annals of Epidemiology
|April 18, 2001
Summary
Racial differences in breast density exist, varying by age. Asian women over 65 had denser breasts than White women, while Black women under 65 showed higher breast density compared to White women.
Area of Science:
- Radiology and Imaging
- Oncology
- Epidemiology
Background:
- Breast density is a significant predictor of breast cancer risk.
- Observed racial disparities in breast cancer incidence necessitate further investigation into contributing factors.
Purpose of the Study:
- To analyze variations in breast density across different racial groups and age demographics.
- To understand how breast density differences correlate with race and age.
Main Methods:
- A cohort of women aged 20-79 underwent screening mammography.
- Breast density was categorized using BI-RADS (Breast Imaging Reporting and Data System) criteria.
- Logistic regression models adjusted for age, parity, menopausal status, hormone replacement therapy, and body mass index.
Main Results:
- Asian women aged over 65 exhibited higher odds of dense breasts compared to White women.
- Black women under 65 showed increased odds of dense breasts relative to White women.
- Hispanic women demonstrated similar breast density patterns to White women across all age groups.
Conclusions:
- Racial variations in breast density do not consistently align with race- and age-specific breast cancer incidence rates.
- Further research is needed to elucidate the complex interplay between race, age, breast density, and breast cancer risk.