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Blood pressure variability in Binswanger's disease and isolated lacunar infarction

J Martí-Fàbregas1, C Valencia, J López-Contreras

  • 1Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. jmarti@hsp.santpau.es

Cerebrovascular Diseases (Basel, Switzerland)
|April 18, 2001
PubMed

Insights

Blood pressure variability is not significantly higher in patients with Binswanger

Area of Science:

  • Neurology
  • Cardiology
  • Geriatrics

Background:

  • Binswanger's disease (BD) is a form of small-vessel disease.
  • Hypertension is a common comorbidity in BD.
  • The relationship between BP variability and BD requires further investigation.

Purpose of the Study:

  • To investigate whether blood pressure (BP) variability is increased in hypertensive patients with Binswanger's disease (BD).

Main Methods:

  • Two groups of treated hypertensive patients were studied: 11 with BD and 16 with lacunar infarction without cognitive impairment.
  • Averaged baseline office BP was recorded for 3 weeks.
  • Ambulatory BP monitoring was used to measure BP variability, defined as the standard deviation of consecutive BP values.

Main Results:

  • Diurnal systolic BP (SBP) variability was initially higher in the BD group (p = 0.04).
  • After adjusting for age and baseline office BP, this difference was no longer statistically significant (p = 0.17 and p = 0.09).
  • Increased BP variability in BD patients appears related to older age and higher baseline BP.

Conclusions:

  • Increased BP variability in Binswanger's disease patients is likely attributable to older age and elevated baseline blood pressure.
  • While increased BP variability may be a risk factor for small-vessel disease, it is not directly linked to cognitive impairment in this context.
Abstract

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