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Carney complex--an unexpected finding during puerperium.

S Schulz1, A Redlich, I Köppe

  • 1Department of Obstetrics and Gynecology, Otto von Guericke University, Gerhart-Hauptmann-Strasse 35, D-39108 Magdeburg, Germany.

Gynecologic and Obstetric Investigation
|April 18, 2001
PubMed
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Carney complex, a rare genetic disorder, can manifest during pregnancy. This case highlights a pregnant woman diagnosed with Carney complex due to primary pigmented nodular adrenocortical disease and Cushing's syndrome.

Area of Science:

  • Endocrinology
  • Genetics
  • Obstetrics

Background:

  • Carney complex is a rare autosomal dominant disorder.
  • It is characterized by multiple neoplasias, lentiginosis, and endocrine abnormalities.
  • Genetic linkage to chromosome 2p16 has been established.

Observation:

  • A 31-year-old pregnant woman presented with severe hypertension, back pain, and cushingoid features at 32 weeks gestation.
  • She underwent an emergency cesarean section due to preeclampsia.
  • Postoperatively, investigations revealed osteopenia, spinal collapse, and a suprarenal mass.

Findings:

  • Histopathology confirmed primary pigmented nodular adrenocortical disease.
  • Biochemical tests confirmed Cushing's syndrome.

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  • The patient met the diagnostic criteria for Carney complex.

    • Implications:

    • This case underscores the importance of recognizing Carney complex in pregnant patients with endocrine and neoplastic manifestations.
    • Early diagnosis and management are crucial for maternal and fetal well-being.
    • Further research into the specific challenges of managing Carney complex during pregnancy is warranted.