Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Response to exercise in upper airway obstruction.

F Al-Bazzaz, H Grillo, H Kazemi

    The American Review of Respiratory Disease
    |May 1, 1975
    PubMed
    Summary

    Mild exercise can cause hypoxemia in patients with upper airway obstruction. Surgical removal of the obstruction resolved exercise hypoxemia in tested patients, suggesting airway resistance is a key factor.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Exploiting within-breed variability in the autochthonous Reggiana breed identified several candidate genes affecting pigmentation-related traits, stature and udder defects in cattle.

    Animal genetics·2021
    Same author

    Genome-wide association studies for the number of teats and teat asymmetry patterns in Large White pigs.

    Animal genetics·2020
    Same author

    Lithium prevents cell apoptosis through autophagy induction.

    Bratislavske lekarske listy·2018
    Same author

    Obesity and spinal loads; a combined MR imaging and subject-specific modeling investigation.

    Journal of biomechanics·2017
    Same author

    Women self-perception of excess hair growth, as a predictor of clinical hirsutism: a population-based study.

    Journal of endocrinological investigation·2015
    Same author

    Cross hospital bed management system.

    Studies in health technology and informatics·2014

    Area of Science:

    • Pulmonary Medicine
    • Respiratory Physiology

    Background:

    • Upper airway obstruction can significantly impact respiratory function during physical activity.
    • Exercise-induced hypoxemia is a recognized clinical phenomenon, but its causes in the absence of diffuse lung disease require further elucidation.

    Purpose of the Study:

    • To investigate the relationship between upper airway obstruction and exercise-induced hypoxemia.
    • To explore the role of increased airway resistance in exertional dyspnea and potential acute respiratory failure.

    Main Methods:

    • Assessed arterial oxygen tension during mild exercise in patients with upper airway obstruction.
    • Evaluated the effect of surgical obstruction removal on exercise hypoxemia.
    • Induce exercise hypoxemia in normal subjects by adding external inspiratory and expiratory resistance.
    • Analyzed airflow mechanics through an orifice to model airway resistance during exercise.

    Main Results:

    • Mild exercise led to a mean decrease of 11 mm Hg in arterial oxygen tension in patients with upper airway obstruction.
    • Exercise hypoxemia resolved post-surgical removal of obstruction in three patients.
    • Four normal subjects developed exercise hypoxemia with added external airway resistance, indicating relative alveolar hypoventilation.

    Conclusions:

    • Upper airway obstruction is a significant cause of exercise-induced hypoxemia.
    • Increased airway resistance during exercise contributes to exertional dyspnea and may precipitate respiratory failure if airway lumen is critically narrowed.
    • Clinicians should consider upper airway obstruction in symptomatic patients, especially those with a history of tracheal intubation or unexplained wheezing during exercise.

    Related Experiment Videos