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Metabolism of N-isopropylacetanilide in rat
G L Larsen1, V J Feil, J E Bakke
1USDA ARS Biosciences Research Laboratory, Fargo, ND 58105, USA. larseng@fargo.ars.usda.gov
Abstract:
1. Radioactivity from oral doses of N-isopropyl[1-14C]acetanilide was excreted in urine (53.5%), faeces (8.1%) and expired air (17.0%) of rat. 2. Enterohepatic circulation occurred during formation of approximately 34% of the metabolites. N-isopropylacetanilide was metabolized by oxidation in all moieties of the molecule with subsequent conjugation with glucuronic and sulphuric acids. 3. The sulphate ester of 4'-hydroxyacetanilide (acetaminophen) was the major metabolite (28 % of the dose).
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