Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does prolonged cyanide exposure have a diabetogenic effect?

B Soto-Blanco1, A B Sousa, H Manzano

  • 1Research Center for Veterinary Toxicology, Department of Pathology, School of Veterinary Medicine, University of São Paulo, SP, Brazil.

Veterinary and Human Toxicology
|April 20, 2001
PubMed
Summary

Chronic cyanide exposure from cassava did not cause diabetes in rats, pigs, or goats. This study suggests cyanide is not the cause of malnutrition-related diabetes mellitus (MRDM) in humans.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cognitive decline outweighs adiposity in influencing lower limb gait kinematics in older adults.

Gait & posture·2026
Same author

Systemic Toxicity of L-Mimosine in Rabbits: A Non-Rodent Model for Safety Assessment.

Journal of applied toxicology : JAT·2025
Same author

Pseudoxanthoma elasticum overlaps hereditary spastic paraplegia type 56.

Journal of internal medicine·2020
Same author

[Experience of implementing the ISO 9001:2015 standard for the accreditation of a paediatric hospital emergency department].

Journal of healthcare quality research·2019
Same author

Maternal feed restriction during pregnancy in Wistar rats: Evaluation of offspring using classical and immunoteratology protocols.

Human & experimental toxicology·2016
Same author

Effects of long-term administration of Senna occidentalis seeds on the hematopoietic tissue of rats.

Toxicon : official journal of the International Society on Toxinology·2015

Area of Science:

  • Toxicology
  • Endocrinology
  • Nutritional Science

Background:

  • Cassava consumption is linked to malnutrition-related diabetes mellitus (MRDM).
  • Experimental evidence linking cyanide exposure to MRDM is limited.
  • Understanding the role of cyanide in MRDM pathogenesis is crucial.

Purpose of the Study:

  • To experimentally investigate the diabetogenic effects of chronic cyanide exposure.
  • To determine if cyanide exposure induces pancreatic pathology or alters glucose metabolism.
  • To assess the potential role of cyanide in the development of MRDM.

Main Methods:

  • Rats, pigs, and goats were administered varying doses of potassium cyanide (KCN) for different durations.
  • Plasma glucose and thiocyanate levels were measured post-exposure.

Related Experiment Videos

  • Pancreatic tissues were examined histopathologically for abnormalities.

    • Main Results:

    • No significant differences in plasma glucose concentrations were observed between control and KCN-exposed groups across all species.
    • Histopathological examination revealed no pancreatic pathology in any of the experimental groups.
    • Chronic cyanide exposure did not induce hyperglycemia or pancreatic damage in rats, swine, or goats.

    Conclusions:

    • Chronic cyanide exposure does not appear to cause diabetes or pancreatic pathology in experimental animals.
    • These findings suggest that cyanide, while present in cassava, may not be the primary causative agent for malnutrition-related diabetes mellitus in humans.
    • Further research is needed to elucidate the complex etiology of MRDM.