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Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
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Change of c-Myc expression and cardiac hypertrophy in patients with aortic valve replacement

S Taketani1, Y Sawa, H Ichikawa

  • 1Department of Surgery Course of Interventional Medicine E1, and Allied Health Sciences, Osaka University Graduate School of Medicine, Japan.

The Annals of Thoracic Surgery
|April 20, 2001
PubMed

Insights

Preoperative c-Myc protein expression in patients with aortic regurgitation (AR) indicates the potential for reversing left ventricular (LV) dysfunction and hypertrophy after aortic valve replacement (AVR). This finding is crucial for predicting recovery outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Molecular Cardiology
  • Cardiac Surgery

Background:

  • Chronic aortic regurgitation (AR) leads to left ventricular (LV) dysfunction that may not resolve after aortic valve replacement (AVR).
  • The protooncogene c-myc has been implicated in the development of cardiac hypertrophy and LV dysfunction in AR patients.
  • The role of c-myc in the reversibility of cardiac changes post-AVR remains unclear.

Purpose of the Study:

  • To investigate the association between preoperative c-myc expression and the reversibility of cardiac hypertrophy and LV dysfunction following AVR in patients with chronic AR.

Main Methods:

  • Twenty patients with isolated chronic AR undergoing AVR were assessed.
  • Left ventricular function, including ejection fraction (EF), end-diastolic volume index (EDVI), and end-systolic volume index (ESVI), was measured pre- and post-AVR.
  • Myocardial c-myc protein expression was quantified preoperatively and post-AVR, alongside measurements of cell diameter (CD) and end-systolic stress (ESS).

Main Results:

  • Post-AVR, LV volumes (ESVI, EDVI) improved, but LV mass index (LVMI) did not normalize in all patients.
  • Preoperative c-myc protein was detected in 16/20 patients; only 2 patients showed expression post-AVR.
  • Preoperative c-myc expression correlated significantly with postoperative cell diameter, ESVI, and ESS/ESVI, and was higher in patients with normalized cardiac parameters.

Conclusions:

  • Preoperative c-myc protein expression serves as a potential biomarker for predicting the reversibility of myocardial cellular hypertrophy and LV dysfunction after AVR in AR patients.
Abstract

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