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Updated: Jul 31, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
Dysphagia caused by a fetus-in-fetu in a 27-year-old man
M G Massad1, L Kong, E Benedetti
1Department of Surgery, The University of Illinois at Chicago, 60612, USA. mmassad@uic.edu
Insights
A rare case of fetus-in-fetu caused a blockage in the esophagus, leading to swallowing difficulties. This highlights the need to consider retroperitoneal masses in diagnosing such symptoms.
Area of Science:
- Medical Case Study
- Surgical Pathology
- Gastroenterology
Background:
- Fetus-in-fetu is a rare congenital anomaly where a malformed fetus is found within the body of its twin.
- Mechanical obstruction of the esophagus is typically caused by other conditions, making this presentation highly unusual.
Observation:
- A 27-year-old male presented with progressive dysphagia (difficulty swallowing).
- Imaging revealed a retroperitoneal cystic mass containing a fetus-in-fetu.
- The mass, present since childhood, had recently caused esophageal compression.
Findings:
- The fetus-in-fetu within the retroperitoneal cyst was identified as the cause of distal esophageal obstruction.
- Surgical intervention was necessary to relieve the mechanical blockage.
Implications:
- This case expands the known clinical manifestations of fetus-in-fetu.
- It suggests that fetus-in-fetu should be included in the differential diagnosis for retroperitoneal masses presenting with esophageal compression or dysphagia.
Abstract:
Mechanical obstruction of the distal esophagus by a fetus-in-fetu is an extremely rare condition that has not been previously reported. We present the case of a 27-year-old man who presented with dysphagia caused by fetus-in-fetu contained within a retroperitoneal cystic cavity. The tumor, noticed since childhood, did not cause any symptoms until a year before presentation when symptoms of dysphagia developed. We propose including this entity in the differential diagnosis of a retroperitoneal mass.
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