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Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase
D L Berge1, M De Ridder, V N Verovski
1Cancer Research Unit, Academic Hospital Free University Brussels, Oncology Center, Laarbeeklaan 101, Brussels, 1090, Belgium.
British Journal of Cancer
|April 20, 2001
Abstract:
Chronic hypoxia up-regulated the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in EMT-6 tumour cells exposed to interferon (IFN)-gamma and interleukin (IL)-I beta. Low concentrations of cytokines (1 unit ml(-1)) in 1% but not in 21% oxygen induced a remarkable increase in NO production and a 1.8-fold hypoxic cell radiosensitization. Therefore, chronic hypoxia may potentially be exploited to increase tumour cell radioresponse through the cytokine-inducible iNOS pathway.