Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nail apparatus melanoma.

K E Thai1, R Young, R D Sinclair

  • 1Department of Medicine (Dermatology), The University of Melbourne, St Vincent's Hospital, Fitzroy, Victoria, Australia.

The Australasian Journal of Dermatology
|April 20, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dutasteride intralesional microinjections in combination with oral minoxidil vs. oral minoxidil monotherapy in men with androgenetic alopecia: a retrospective analysis of 105 patients.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Systemic minoxidil as maintenance treatment in alopecia areata: a retrospective case series of 24 patients.

Clinical and experimental dermatology·2021
Same author

Sublingual minoxidil for the treatment of male and female pattern hair loss: a randomized, double-blind, placebo-controlled, phase 1B clinical trial.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Topical tofacitinib for the treatment of alopecia areata affecting facial hair.

The British journal of dermatology·2021
Same author

Global expression profile and global genome methylation signatures in male patients with androgenetic alopecia.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Prostaglandins in androgenetic alopecia in 12 men and four female.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019

Nail apparatus melanoma, a rare but deadly cancer, lacks clear causes and diagnostic criteria. Early detection and surgical excision are crucial for survival, as other treatments show no benefit.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Nail apparatus melanoma is a rare melanoma variant with high mortality.
  • Its etiology, natural history, and epidemiological associations are poorly understood.
  • Diagnostic criteria for early nail apparatus melanoma are not universally defined.

Purpose of the Study:

  • To review the current understanding of nail apparatus melanoma.
  • To highlight diagnostic challenges and treatment strategies.
  • To emphasize the importance of early detection and surgical intervention.

Main Methods:

  • Literature review of existing studies on nail apparatus melanoma.
  • Analysis of clinical and histological features.
  • Evaluation of treatment outcomes and survival data.

Related Experiment Videos

Main Results:

  • Key clinical signs include melanonychia striata and Hutchinson's sign, though not pathognomonic.
  • Diagnostic delays are common, leading to advanced disease at diagnosis.
  • Surgical excision is the primary treatment for early-stage disease; optimal margins and amputation levels require further definition.

Conclusions:

  • Early diagnosis and surgical excision are paramount for improving survival in nail apparatus melanoma.
  • Adjuvant therapies like chemotherapy and lymph node dissection have not demonstrated survival benefits.
  • Further research is needed to establish definitive diagnostic criteria and optimal treatment guidelines.