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Subendometrial contractility is not predictive for in vitro fertilization (IVF) outcome
V Vlaisavljevic1, M Reljic, V Gavric-Lovrec
1Department of Reproductive Medicine and Gynecologic Endocrinology, Maribor Teaching Hospital, Maribor, Slovenia. vlai@sb-mb.si
Summary
Endometrial thickness on day +12 may predict in vitro fertilization success. However, endometrial movement and hormone levels on earlier days showed no significant impact on pregnancy outcomes.
Area of Science:
- Reproductive endocrinology
- In vitro fertilization (IVF)
- Reproductive medicine
Background:
- Assessing IVF success relies on various factors.
- Endometrial receptivity is crucial for successful implantation.
- Predictive markers for IVF outcomes are continuously sought.
Purpose of the Study:
- To determine if endometrial thickness, pattern, movement, and serum hormone levels (estradiol, progesterone) influence IVF outcomes.
- To identify reliable predictors of successful pregnancy following IVF.
Main Methods:
- Prospective analysis of 122 IVF cycles.
- Measurements of endometrial thickness, pattern, and subendometrial activity.
- Serum estradiol and progesterone levels were assessed at specific time points (day -2, +2, +6, +12).
Main Results:
- Pregnant women showed a trend towards thicker endometria on day +12.
- No significant differences in endometrial movement or thickness were observed between pregnant and non-pregnant groups on days +2 and +6.
- Serum estradiol and progesterone levels did not significantly differ on days +2 and +6.
- Only progesterone levels on day +12 emerged as a potential predictor of IVF outcome when combined with echographic variables.
Conclusions:
- Subendometrial contractility does not appear to play a significant role in implantation.
- Endometrial thickness on day +12 may be a more relevant indicator of implantation success than earlier measurements or endometrial movement.