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Indomethacin treatment of pericarditis in chronic hemodialysis patients

A N Minuth, G A Nottebohm, G Eknoyan

    Archives of Internal Medicine
    |June 1, 1975
    PubMed

    Insights

    Indomethacin effectively treats symptomatic pericarditis in hemodialysis patients, reducing the need for invasive procedures like pericardiocentesis. Early treatment and continued use are key for symptom relief and preventing recurrence.

    Area of Science:

    • Nephrology
    • Cardiology
    • Internal Medicine

    Background:

    • Symptomatic pericarditis is a complication of maintenance hemodialysis.
    • Conventional treatments and pericardiectomy are often required.
    • Dialysis-associated pericarditis can be challenging to manage.

    Purpose of the Study:

    • To evaluate the efficacy of indomethacin in treating symptomatic pericarditis in hemodialysis patients.
    • To compare indomethacin treatment with other conventional measures.
    • To determine if indomethacin can prevent the need for invasive procedures.

    Main Methods:

    • A cohort of 11 hemodialysis patients with symptomatic pericarditis was studied.
    • Eight patients received indomethacin treatment.
    • Treatment response, need for pericardiocentesis, and recurrence rates were monitored.

    Main Results:

    • Indomethacin led to rapid defervescence and pain relief within 6-24 hours in eight patients.
    • Only one patient receiving indomethacin required pericardiocentesis.
    • Symptoms recurred upon discontinuation of indomethacin within the first week.
    • Dosage could be tapered after 3 weeks to 4 months of treatment.

    Conclusions:

    • Indomethacin is effective for treating dialysis-associated pericarditis.
    • Indomethacin can preclude the need for invasive procedures like pericardiocentesis.
    • Sustained treatment is necessary to prevent symptom recurrence.

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