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Serum IgD levels in children with atopic asthma. A longitudinal study
D C Salpietro1, A Masaracchio, A Turiaco
1Servizio di Genetica Medica, Istituto di Pediatria Medica Preventiva e Sociale, Università degli Studi, Messina, Italy.
Background:
Serum IgD and IgE levels were measured in children with atopic asthma and in control Group in order to determine their relationship with clinical status.
Methods:
Samples of venous blood (of 5 cc) were drawn from 25 asthmatic children (Group A) and 25 healthy children (Group B) at the moment of first diagnosis (T0), after 6 months (T180) and after 18 months (T540). To measure IgD, an ELISA assay based on the sandwich principle was used.
Results:
At T0, IgD were significantly higher in Group A (182.7 5+/-88.18 IU/ml) in comparison with Group B (69.58+/-4.93 IU/ml, p<0.0001); IgD levels decreased in Group A at T540.
Conclusions:
In conclusion, a significant increase of IgD levels observed in children at first signs of asthma and the following normalization of these same levels after 18 months, may represent a non specific response or an attempt of the organism to block asthma, favouring therefore immunologic tolerance.