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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

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Cognitive function in postmenopausal women treated with raloxifene.

K Yaffe¹, K Krueger, S Sarkar

¹Department of Psychiatry, University of California at San Francisco, 94121, USA.

The New England Journal of Medicine

|April 20, 2001

Summary

Raloxifene did not impact cognitive scores in postmenopausal women with osteoporosis over three years. This study investigated raloxifene

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Area of Science:

Neuroscience
Gerontology
Pharmacology

Background:

Estrogen may benefit postmenopausal women's cognition.
Raloxifene, a selective estrogen-receptor modulator, is investigated for cognitive effects.

Purpose of the Study:

To determine if raloxifene influences cognitive function in postmenopausal women with osteoporosis.

Main Methods:

7478 postmenopausal women with osteoporosis were randomized to raloxifene (60 or 120 mg) or placebo for three years.
Cognitive function was assessed using six tests at baseline and various intervals up to three years.
Cognitive decline was defined as a score change in the worst 10 percent.

Main Results:

Cognitive scores showed slight improvement across all groups, with no significant differences.
Raloxifene did not significantly alter the risk of cognitive decline on most tests.
A trend towards reduced decline in verbal memory and attention was observed with raloxifene.

Conclusions:

Three-year raloxifene treatment did not affect overall cognitive scores in postmenopausal women with osteoporosis.