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The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
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Published on: February 3, 2012

Autoimmune hepatitis

M L Ellett1

  • 1Indiana University School of Nursing, Family Health, Room 451L, 1111 Middle Drive, Indianapolis, IN 46202-5107, USA.

Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates
|April 20, 2001
PubMed

Autoimmune hepatitis (AIH) is a necro-inflammatory disease that, untreated, carries a 3-year mortality rate of approximately 50%. In this last of a series of three articles, current knowledge regarding AIH is reviewed. The mode of presentation of AIH is variable: insidious onset with few if any symptoms, presenting with symptoms indistinguishable from that of any acute viral hepatitis, or onset with fulminate hepatitis. In AIH, hepatocytes become injured by various agents (such as a viral infection) and become antigenic, leading to a self-perpetuating antigen-antibody response with subsequent chronic liver disease. AIH is the only type of hepatitis that is responsive to corticosteroids. Occasionally, AIH develops after liver transplantation.

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