Enamel matrix derivative in periodontal reconstructive surgery. A new approach in periodontal regeneration

True periodontal regeneration is the goal of any periodontal regenerative techniques. Cementum formation is a key event in the development of root and supporting periodontium. Due to its distribution, acellular cementum is the type most affected by early to moderate periodontitis. Studies over the past twenty years demonstrated that, enamel matrix proteins from the root sheath are involved in the formation of acellular, during tooth development. Thus the adjunctive use of enamel matrix derivatives in conjunction with regenerative periodontal surgery could possibly lead to true periodontal regeneration. The purpose of this article is to review the use of enamel matrix derivative in true periodontal regeneration.