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Related Experiment Videos

Metabolism 2000: the emperor needs new clothes.

V R Young1, A M Ajami

  • 1Laboratory of Human Nutrition, School of Science and Clinical Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. vryoung@mit.edu

The Proceedings of the Nutrition Society
|April 20, 2001
PubMed
Summary

Metabolic research, using tracers as phenotyping tools, offers a new way to link genomics with whole-body physiology. This approach defines quantitative metabolic phenotypes for a deeper understanding of the

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Area of Science:

  • Nutritional Science
  • Metabolic Research
  • Genomics

Background:

  • The post-genomic era necessitates linking reductionist biological advances with observational studies.
  • Metabolism is central to nutritional science, bridging molecular biology and whole-organism studies.
  • A reconstructive, metabolism-focused approach enhances nutritional science paradigms.

Discussion:

  • Tracer technology serves as a key phenotyping tool in metabolic studies.
  • Novel metabolic concepts include 'underground metabolism,' 'metabolic hijacking,' 'catalytic promiscuity,' and 'moonlighting proteins.'
  • Emerging technologies and interdisciplinary research are crucial for advancing metabolic studies.

Key Insights:

  • Metaprobe concepts yield quantitative physiological (metabolic) phenotypes for genotype correlation.

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  • Whole-body or kinetically discernible metabolic phenotypes are ideal for defining the 'functional' genotype.
  • Tracer-based measurement of metabolic turnover, change, and conversion is essential.

    • Outlook:

    • Metabolism, probed with tracers, acts as a portal to the 'Genomics Internet.'
    • This approach facilitates the exploration of metabolic characteristics within the broader genomic landscape.
    • Future research will leverage these tools for a more integrated understanding of biology.