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Effectiveness and infant acceptance of the Rx medibottle versus the oral syringe

D M Kraus1, L A Stohlmeyer, P R Hannon

  • 1Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, 60612, USA.

Pharmacotherapy
|April 20, 2001
PubMed

Insights

The Rx medibottle significantly improved medication adherence and infant acceptance compared to standard oral syringes. This novel drug delivery method ensures more infants receive their full prescribed dose, enhancing treatment effectiveness.

Area of Science:

  • Pediatric pharmacology
  • Drug delivery systems
  • Clinical trial methodology

Background:

  • Accurate medication administration to infants is crucial for effective treatment.
  • Standard oral syringes can lead to suboptimal dosing and poor infant acceptance.
  • Novel drug delivery devices are needed to improve pediatric medication adherence.

Purpose of the Study:

  • To compare the effectiveness and infant acceptance of the Rx medibottle versus a standard oral syringe for liquid medication delivery.
  • To evaluate the percentage of infants receiving the full intended dose with each device.
  • To assess infant acceptance using a validated scale.

Main Methods:

  • Prospective, open-label, randomized, crossover clinical study.
  • Thirty healthy, bottle-fed infants (2-14 months) received acetaminophen via Rx medibottle and oral syringe.
  • Effectiveness measured by 100% dose delivery; acceptance measured by Medication Acceptance Scale (MAS).

Main Results:

  • Rx medibottle delivered 100% of the intended dose in 93.3% of infants, versus 56.7% for oral syringe (p=0.0074).
  • Mean MAS scores were significantly higher for Rx medibottle (8.3) than oral syringe (7.3) (p=0.002).
  • Ideal MAS scores (≥9) were achieved by 73% with Rx medibottle vs. 17% with oral syringe (p=0.0001).

Conclusions:

  • The Rx medibottle is a more effective drug delivery method than standard oral syringes.
  • Infant acceptance of medication is significantly higher with the Rx medibottle.
  • This device holds potential for improving infant adherence to liquid medications.
Abstract

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