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Ring-deactivated hydroxymethylpyrroles as inhibitors of alpha-chymotrypsin
1Department of Chemistry, University of Canterbury, Christchurch, New Zealand. a.abell@chem.canterbury.ac.nz
Bioorganic & Medicinal Chemistry
|April 20, 2001
Abstract:
N-Acyl and N-sulfonylhydroxymetyhylpyrroles have been synthesised and shown to inhibit alpha-chymotrypsin. A hydrophobic group in the N-substituent has been shown to be required for activity.