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Identification and structural determination of a potent P-selectin inhibitor
N Kaila1, G Y Xu, R T Camphausen
1Department of Chemical Sciences, Wyeth Research, Cambridge, MA 02140, USA. nkaila@genetics.com
Bioorganic & Medicinal Chemistry
|April 20, 2001
Abstract:
Small quantities of a potent P-selectin inhibitor, 2 (IC50 = 0.2 microM), were isolated and an initial structure proposed based on 1D proton NMR. A reterosynthetic analysis of the proposed structure led us to a total synthesis of 2. NMR studies using the 2-D homo-TOCSY and NOESY and 2-D hetero-HMQC helped to confirm the structure of 2.